Here is the list of former Valley League players who have appeared in the major leagues. Before 1994 information is difficult to find; therefore, some players and details might be missing. (Updated May, 2022)
| Last | First | Position | Team | Year | Round | Draft | Yrs in Majors |
| Abad | Andy | 1B | Harrisonburg | 1993 | 16 | 1993 | 2001-2006 |
| Adams | Austin | RHP | Staunton | 2011 | 8 | 2012 | 2017- |
| Adams | Mike | RHP | Front Royal | FA | 2001 | 2004-2014 | |
| Allison | Dana | LHP | Front Royal | 1986 | 21 | 1989 | 1991 |
| Alonso | Yonder | 1B | Luray | 2006 | 1 (7) | 2008 | 2010-2019 |
| Anderson | Justin | RHP | Front Royal | 2013 | 14 | 2014 | 2018- |
| Arnold | Tony | RHP | Staunton | 10 | 1981 | 1986-1987 | |
| Austin | Jim | RHP | Staunton | 6 | 1986 | 1991-1993 | |
| Barkett | Andy | 1B | Winchester | 1992 | FA | 1995 | 2001 |
| Barnes | Brian | LHP | Staunton | 4 | 1989 | 1990-1994 | |
| Battle | Allen | OF | Front Royal | 10 | 1991 | 1995-1996 | |
| Beachy | Brandon | RHP | Woodstock | 2008 | FA | 2008 | 2010-2015 |
| Bean | Colter | RHP | Winchester | 1997 | FA | 2000 | 2005-2007 |
| Benedict | Bruce | C | Waynesboro | 1975 | 5 | 1976 | 1978-1989 |
| Billingsley | Brent | LHP | New Market | 1995 | 5 | 1996 | 1999 |
| Bocock | Brian | SS | Luray | 2004 | 9 | 2006 | 2008-2010 |
| Booker | Greg | RHP | Waynesboro | 10 | 1981 | 1983-1990 | |
| Bradley | Tom | RHP | Luray | 7 | 1968 | 1969-1975 | |
| Brewington | Jamie | RHP | New Market | 1992 | 10 | 1992 | 1995-2000 |
| Briley | Greg | OF | 1 (12) | 1986 | 1988-1993 | ||
| Brookens | Tom | 3B | Waynesboro | 1 (4) | 1975 | 1979-1990 | |
| Brosseau | Michael | 3B | Waynesboro | 2015 | FA | 2016 | 2019- |
| Brown | Emil | OF | Waynesboro | 1993 | 6 | 1994 | 1997-2009 |
| Browning | Tom | LHP | New Market | 1980-1 | 9 | 1982 | 1984-1995 |
| Burke | Greg | RHP | Front Royal | 2001 | FA | 2006 | 2009-2013 |
| Burton | Jared | RHP | New Market | 2001 | 8 | 2002 | 2007-2014 |
| Butler | Joey | OF | New Market | 2006 | 15 | 2008 | 2013-2015 |
| Caldwell | Mike | LHP | Charlottesville | 1968 | 12 | 1971 | 1971-1984 |
| Cali | Carmen | LHP | Staunton | 1998 | 10 | 2000 | 2004-2007 |
| Camp | Shawn | RHP | Staunton | 1997 | 16 | 1997 | 2004-2014 |
| Campbell | Eric | 3B | Luray | 2006 | 8 | 2008 | 2014-2016 |
| Cannizaro | Andy | SS | Waynesboro | 1998 | 7 | 2001 | 2006-2008 |
| Cardullo | Stephen | OF | Covington | 2007 | 24 | 2010 | 2016-2017 |
| Carpenter | David | RHP | Covington | 2004 | 12 | 2006 | 2011-2015 |
| Cherry | Rocky | RHP | Harrisonburg | 2001 | 14 | 2002 | 2007-2008 |
| Christopher | Mike | RHP | Winchester | 1984 | 7 | 1985 | 1991-1996 |
| Citarella | Ralph | RHP | Staunton | 1 (15) | 1979 | 1983-1987 | |
| Cockrell | Alan | OF | Staunton | 1 (9) | 1984 | 1996 | |
| Comer | Wayne | OF | Shenandoah | 1961 | 1967-1972 | ||
| Copeland | Scott | RHP | Staunton | 2007 | 21 | 2010 | 2015-2018 |
| Corcoran | Roy | RHP | Harrisonburg | 1998 | FA | 2001 | 2003-2009 |
| Correll | Vic | C | Staunton | 9 | 1967 | 1972-1980 | |
| Cousins | Scott | OF | Harrisonburg | 2005 | 3 | 2006 | 2010-2013 |
| Cowgill | Collin | OF | Covington | 2005 | 5 | 2008 | 2011-2016 |
| Croushore | Rich | RHP | Harrisonburg | 1991 | FA | 1993 | 1998-2000 |
| Cubbage | Mike | 3B | Charlottesville | 1968-9 | 2 | 1971 | 1974-1981 |
| Dascenzo | Doug | OF | Front Royal | 12 | 1985 | 1988-1996 | |
| Davidson | Mark | OF | Winchester | 1982 | 11 | 1982 | 1986-1991 |
| Decker | Steve | C | Front Royal | 21 | 1988 | 1990-1999 | |
| Delaney | Rob | RHP | New Market | 2003 | FA | 2006 | 2010-2011 |
| Dennick | Ryan | LHP | Fauquier | 2008 | 22 | 2009 | 2014 |
| Deshaies | Jim | LHP | Madison | 21 | 1982 | 1984-1995 | |
| Devenski | Chris | RHP | Woodstock | 2011 | 25 | 2011 | 2016- |
| Dickson | Brandon | RHP | New Market | 2006 | FA | 2006 | 2011-2012 |
| Dinges | Vance | 1B | Harrisonburg | FA | 1938 | 1945-1946 | |
| Dobnak | Randy | RHP | Front Royal | 2015 | FA | 2017 | 2019- |
| Donovan | Brendan | OF | New Market | 2016 | 7 | 2018 | 2022- |
| Eckstein | David | 2B | Harrisonburg | 1995-6 | 19 | 1997 | 2001-2010 |
| Edgin | Josh | LHP | Winchester | 2007 | 30 | 2010 | 2012-2017 |
| Egbert | Jack | RHP | Winchester | 2003 | 13 | 2004 | 2009-2012 |
| Engel | Steve | RHP | Staunton | 5 | 1983 | 1985 | |
| Esposito | Brian | C | Staunton | 5 | 2000 | 2007-2010 | |
| Everett | Adam | SS | Winchester | 1996 | 1 (12) | 1998 | 2001-2011 |
| Finley | Steve | OF | Harrisonburg | 1985 | 13 | 1987 | 1989-2007 |
| Fireovid | Steve | RHP | Waynesboro | 1975 | 7 | 1978 | 1981-1992 |
| Fischer | Jeff | RHP | 7 | 1985 | 1987-1989 | ||
| Flaherty | John | C | Front Royal | 25 | 1988 | 1992-2005 | |
| Foppert | Jesse | RHP | Harrisonburg | 2000 | 2 | 2001 | 2003-2005 |
| Fox | Matt | RHP | Staunton | 2003 | 1 (35) | 2004 | 2010 |
| Gardner | Brett | OF | New Market | 2003 | 3 | 2005 | 2008-2021 |
| Garrett | Reed | RHP | New Market | 2013 | 16 | 2014 | 2019 |
| Godby | Danny | OF | Harrisonburg | FA | 1968 | 1974 | |
| Gomber | Austin | LHP | Luray | 2012 | 4 | 2014 | 2018- |
| Gonzalez | Orlando | 1B | Harrisonburg | 18 | 1974 | 1976-1980 | |
| Gonzalez | Romy | 2B | Staunton | 2016 | 18 | 2018 | 2021- |
| Gregorio | Tom | C | Staunton | 27 | 1999 | 2003 | |
| Gronkiewicz | Lee | RHP | New Market | 1998 | FA | 2001 | 2007 |
| Grubb | John | OF | Charlottesville | 1969 | 1 (24) | 1971 | 1972-1987 |
| Guevara | Carlos | RHP | Covington | 2002 | 7 | 2003 | 2008 |
| Guetterman | Lee | LHP | Waynesboro | 4 | 1981 | 1984-1996 | |
| Harris | Will | RHP | Staunton | 2003 | 9 | 2006 | 2012- |
| Harris | Greg | RHP | Front Royal | 10 | 1985 | 1988-1995 | |
| Heffernan | Bert | C | Winchester | 1985 | 9 | 1988 | 1992 |
| Hernandez | Roberto | RHP | Front Royal | 1 (16) | 1986 | 1991-2007 | |
| Hibbard | Greg | LHP | Staunton | 16 | 1986 | 1989-1994 | |
| Hill | Taylor | RHP | Winchester | 2008 | 6 | 2011 | 2014-2015 |
| Hill | Garry | RHP | Harrisonburg | 1 (8) | 1967 | 1969 | |
| Hodges | Ron | C | Harrisonburg | 2 | 1972 | 1973-1984 | |
| Hoiles | Chris | C | Harrisonburg | 1985 | 19 | 1986 | 1989-1998 |
| Holland | Al | LHP | Charlottesville | 4 | 1975 | 1977-1987 | |
| Honeycutt | Rick | LHP | Charlottesville | 1973 | 17 | 1976 | 1977-1997 |
| Howard | Sam | LHP | Staunton | 2012 | 3 | 2014 | 2018- |
| Hubbard | Mike | C | Harrisonburg | 1990 | 8 | 1992 | 1995-2001 |
| Hudek | John | RHP | Front Royal | 10 | 1988 | 1994-1999 | |
| Huff | Aubrey | 3B | Staunton | 1997 | 5 | 1998 | 2000-2012 |
| Hunt | Randy | C | Winchester | 1980 | 1 (2) | 1981 | 1985-1986 |
| Hurst | Jonathan | RHP | Front Royal | 1986 | 4 | 1987 | 1992-1994 |
| Inge | Brandon | 3B | Waynesboro | 1996 | 2 | 1998 | 2001-2013 |
| Irvine | Daryl | RHP | Harrisonburg | 1984 | 1 (20) | 1985 | 1990-1992 |
| Jay | Jon | OF | Staunton | 2004 | 2 | 2006 | 2010-2021 |
| Johnson | Jeff | LHP | Winchester | 1986 | 6 | 1988 | 1991-1993 |
| Johnson | Sherman | 2B | Covington | 2009-10 | 14 | 2012 | 2018 |
| Jones | Darryl | OF | Madison | 5 | 1972 | 1979 | |
| Jones | Hunter | LHP | Winchester | 2003 | FA | 2005 | 2009-2010 |
| Jones | Lynn | OF | Shenandoah | 10 | 1974 | 1979-1986 | |
| Jordan | Scott | OF | Winchester | 1982 | 4 | 1985 | 1988 |
| Judy | Josh | RHP | Haymarket | 2006-7 | 34 | 2007 | 2011 |
| Kelly | Pat | 2B | Staunton | 9 | 1988 | 1991-1999 | |
| Kensing | Logan | RHP | Harrisonburg | 2002 | 2 | 2003 | 2004-2016 |
| Key | Jimmy | LHP | Winchester | 1980 | 3 | 1982 | 1984-1998 |
| Kipnis | Jason | OF | Covington | 2006-7 | 2 | 2009 | 2011-2020 |
| Knudson | Guido | RHP | Woodstock | 2009 | 28 | 2011 | 2015 |
| Koshansky | Joe | 1B | Staunton | 2002-3 | 6 | 2004 | 2007-2008 |
| Kouzmanoff | Kevin | 3B | Winchester | 2002 | 6 | 2003 | 2006-2014 |
| Kratz | Erik | C | Waynes-Har | 2000-01 | 29 | 2002 | 2010-2020 |
| Kruk | John | 1B | New Market | 1981 | 3 | 1981 | 1986-1995 |
| Kuhl | Chad | RHP | New Market | 2012 | 9 | 2013 | 2016- |
| LaStella | Tommy | 2B | Haymarket | 2009 | 8 | 2011 | 2014- |
| Leathersich | Jack | LHP | Haymarket | 2009 | 5 | 2011 | 2015-2017 |
| Lee | Corey | LHP | Staunton | 1(32) | 1996 | 1999 | |
| Leftwich | Phil | RHP | Front Royal | 2 | 1990 | 1993-1996 | |
| Lemonds | Dave | LHP | Harrisonburg | 1 (1) | 1968 | 1969, 1972 | |
| Lewis | Darren | OF | Harrisonburg | 18 | 1988 | 1990-2002 | |
| Liberatore | Adam | LHP | Waynesboro | 2007-8 | 21 | 2010 | 2015 |
| Lopez | Javier | LHP | New Market | 1996 | 4 | 1998 | 2003-2016 |
| Lopez | Luis | 3B | Winchester | 1992-3 | 2001-2004 | ||
| Lowell | Mike | 3B | Waynesboro | 1993 | 20 | 1995 | 1998-2010 |
| Lusader | Scott | OF | Winchester | 1984 | 6 | 1985 | 1987-1991 |
| Lynch | Ed | RHP | Madison | 22 | 1977 | 1980-1987 | |
| Maloney | Sean | RHP | Harrisonburg | 1990 | 19 | 1993 | 1997-1998 |
| Manto | Jeff | 3B | Front Royal | 14 | 1985 | 1990-2000 | |
| Manwaring | Kirt | C | Harrisonburg | 1985 | 2 | 1986 | 1987-1999 |
| Manzella | Thomas | SS | Waynesboro | 2002 | 3 | 2005 | 2009-2010 |
| Margevicius | Nick | LHP | Staunton | 2015 | 7 | 2017 | 2019- |
| Maroth | Mike | LHP | Staunton | 1996-7 | 3 | 1998 | 2002-2007 |
| Martin | Renie | RHP | New Market | 19 | 1977 | 1979-1984 | |
| Martin | Tom | LHP | Front Royal | 1987 | 6 | 1988 | 1997-2007 |
| Martinez | Luis | C | Harrisonburg | 2005 | 12 | 2007 | 2011-2012 |
| May | Jerry | C | Staunton | 1960 | 1964-1973 | ||
| Mazeika | Patrick | C | Waynesboro | 2013 | 8 | 2015 | 2021- |
| McBeth | Marcus | RHP | New Market | 1999 | 4 | 2001 | 2007 |
| McBroom | Ryan | 1B | Haymarket | 2011-12 | 15 | 2014 | 2019- |
| McDougall | Marshall | 3B | New Market | 1998 | 9 | 2000 | 2005 |
| McGrath | Kyle | LHP | Staunton | 2011 | 36 | 2014 | 2017 |
| McNichol | Brian | LHP | Winchester | 1994 | 2 | 1995 | 1999 |
| Meacham | Rusty | RHP | Winchester | 1987 | 33 | 1987 | 1991-2001 |
| Meadows | Louie | OF | Staunton | 2 | 1982 | 1986-1990 | |
| Meisinger | Ryan | RHP | Staunton | 2014 | 11 | 2015 | 2018- |
| Menechino | Frank | 2B | Harrisonburg | 1992 | 45 | 1993 | 1999-2005 |
| Michaels | Jason | OF | Staunton | 1995 | 4 | 1998 | 2001-2011 |
| Mills | Brad | LHP | Harrisonburg | 2005 | 4 | 2007 | 2009-2015 |
| Mitchell | Larry | RHP | Harrisonburg | 1990 | 5 | 1992 | 1996 |
| Mordecai | Mike | 3B | Staunton | 1987 | 6 | 1989 | 1994-2005 |
| Mosebach | Robert | RHP | Woodstock | 2004 | 9 | 2005 | 2009 |
| Moyer | Jaime | LHP | Harrisonburg | 6 | 1984 | 1986-2012 | |
| Munoz | Oscar | RHP | Harrisonburg | 5 | 1990 | 1995 | |
| Murphy | Daniel | 3B | Luray | 2004-05 | 13 | 2006 | 2008-2020 |
| Murphy | Tommy | OF | Staunton | 1998 | 3 | 2000 | 2006-2007 |
| Mutis | Jeff | LHP | Staunton | 1(27) | 1988 | 1991-1994 | |
| Nabholz | Chris | LHP | Front Royal | 2 | 1988 | 1990-1995 | |
| Noel | Rico | OF | Covington | 2008 | 5 | 2010 | 2015 |
| Nordbrook | Tim | SS | Harrisonburg | 9 | 1970 | 1974-1979 | |
| Nunnari | Talmadge | 1B | Harrisonburg | 1996 | 9 | 1997 | 2000 |
| O’Connor | Mike | LHP | New Market | 2001 | 7 | 2002 | 2006-2011 |
| Oates | Johnny | C | Waynesboro | 1965-6 | 1(10) | 1967 | 1970-1981 |
| Odom | Joseph | C | Winchester | 2012 | 13 | 2013 | 2020- |
| Olson | Tim | 3B | Staunton | 1999-00 | 7 | 2000 | 2004-2005 |
| Pagan | Emilio | RHP | Harrisonburg | 2010 | 10 | 2013 | 2017- |
| Pankovits | Jim | 2B | Harrisonburg | 1974 | 4 | 1976 | 1984-1990 |
| Paschall | Bill | RHP | Waynesboro | 3 | 1976 | 1978-1981 | |
| Pasqua | Dan | 1B | New Market | 1981 | 3 | 1982 | 1985-1994 |
| Patterson | Bob | LHP | Madison | 1981 | 21 | 1982 | 1985-1998 |
| Pawlowski | John | RHP | Staunton | 6 | 1985 | 1987-1988 | |
| Payne | Tyler | C | Strasburg | 2013-14 | 30 | 2015 | 2021- |
| Pearson | Nate | RHP | Staunton | 2016 | 1(28) | 2017 | 2020- |
| Pennington | Cliff | SS | Harrisonburg | 2003 | 1(21) | 2005 | 2008-2018 |
| Perez | Chris | RHP | Staunton | 2004 | 1(42) | 2006 | 2008-2014 |
| Perlozzo | Sam | 2B | Way, NM | 1970-72 | FA | 1972 | 1977-1979 |
| Pierre | Juan | OF | Harrisonburg | 1997 | 13 | 1998 | 2000-2013 |
| Poole | Jim | LHP | Staunton | 9 | 1988 | 1990-2000 | |
| Porter | Chuck | RHP | Madison | 7 | 1976 | 1981-1985 | |
| Povse | Max | RHP | Staunton | 2013 | 3 | 2014 | 2017 |
| Pryor | Greg | 3B | Harrisonburg | 6 | 1971 | 1976-1986 | |
| Pye | Eddie | SS | Front Royal | 10 | 1988 | 1994-1995 | |
| Rauch | Jon | RHP | Harrisonburg | 1998 | 3 | 1999 | 2002-2013 |
| Ray | Chris | RHP | New Market | 2001 | 3 | 2003 | 2005-2011 |
| Raynor | John | OF | New Market | 2004 | 9 | 2006 | 2010 |
| Reese | Kevin | OF | Winchester | 1998 | 27 | 2000 | 2005-2006 |
| Regilio | Nick | RHP | Staunton | 1998 | 2 | 1999 | 2004-2005 |
| Richards | Gene | OF | Harrisonburg | 1974 | 1(1) | 1975 | 1977-1984 |
| Richardson | Antoan | OF | Winchester | 2003 | 35 | 2005 | 2011-2014 |
| Rivera | Saul | RHP | New Market | 1997 | 9 | 1998 | 2006-2010 |
| Roach | Jason | RHP | Winchester | 1995-6 | 20 | 1997 | 2003 |
| Robinson | Clint | 1B | Harrisonburg | 2005-6 | 25 | 2007 | 2012-2016 |
| Rodriguez | Eddy | C | Luray | 2005-6 | 20 | 2006 | 2012 |
| Rodriguez | Freddy | RHP | Harrisonburg | 1958-1959 | |||
| Rodriguez | Rich | LHP | Staunton | 9 | 1984 | 1990-2003 | |
| Rucinski | Drew | RHP | Luray | 2008-10 | FA | 2011 | 2014- |
| Sample | Billy | OF | Harrisonburg | 1974-6 | 10 | 1976 | 1978-1986 |
| Sanchez | Gaby | 1B | Staunton | 2003 | 4 | 2005 | 2008-2014 |
| Sanders | Reggie | OF | Winchester | 1987 | 7 | 1987 | 1991-2007 |
| Savage | Jack | RHP | 8 | 1985 | 1987-1990 | ||
| Schimpf | Ryan | 2B | Luray | 2008 | 5 | 2009 | 2016-2018 |
| Scott | Robby | LHP | Covington | 2010 | FA | 2011 | 2016-2018 |
| Scott | Luke | OF | Staunton | 9 | 2001 | 2005-2013 | |
| Shealy | Ryan | 1B | Harrisonburg | 1999 | 11 | 2002 | 2005-2010 |
| Shields | Tom | 2B | Front Royal | 15 | 1986 | 1992-1993 | |
| Smith | Dan | LHP | Staunton | 1(16) | 1990 | 1992-1994 | |
| Smitherman | Stephen | OF | Winchester | 1998-9 | 23 | 2000 | 2003 |
| Snyder | Kyle | RHP | Winchester | 1997 | 1(7) | 1999 | 2003-2008 |
| Spangenberg | Cory | 2B | Winchester | 2010 | 1(10) | 2011 | 2014-2018 |
| Stamets | Eric | SS | Haymarket | 2010 | 6 | 2012 | 2019 |
| Stavinoha | Nick | OF | Front Royal | 2003 | 7 | 2005 | 2008-2010 |
| Stewart | Sam | RHP | Staunton | 1974 | 28 | 1974 | 1978-1987 |
| Stone | George | LHP | Staunton | 5 | 1966 | 1967-1975 | |
| Stoner | Tobi | RHP | Front Royal | 2005 | 16 | 2006 | 2009-2010 |
| Stout | Eric | LHP | Waynesboro | 2012 | 13 | 2014 | 2018- |
| Strange | Doug | 3B | Harrisonburg | 7 | 1985 | 1989-1998 | |
| Swisher | Steve | C | Harrisonburg | 1(21) | 1973 | 1974-1982 | |
| Tam | Jeff | RHP | Harrisonburg | 1992 | 1998-2003 | ||
| Tatum | Craig | C | Covington | 2002 | 3 | 2004 | 2009-2011 |
| Tekotte | Blake | OF | Woodstock | 2006 | 3 | 2008 | 2011-2013 |
| Terrell | Walt | RHP | Staunton | 15 | 1979 | 1982-1992 | |
| Thornburg | Tyler | RHP | Winchester | 2008 | 3 | 2010 | 2012-2018 |
| Timpner | Clay | OF | Staunton | 2002 | 4 | 2004 | 2008 |
| Tobik | Dave | RHP | 1(2) | 1975 | 1978-1985 | ||
| Tolleson | Wayne | SS | Staunton | 8 | 1978 | 1981-1990 | |
| Tolliver | Ashur | LHP | Harrisonburg | 2007 | 5 | 2009 | 2016-2017 |
| Tracy | Chad | 3B | Staunton | 1999 | 7 | 2001 | 2004-2013 |
| Vaughn | Mo | 1B | Harrisonburg | 1987 | 1(23) | 1989 | 1991-2003 |
| Venafro | Mike | LHP | New Market | 1994 | 29 | 1995 | 1999-2006 |
| Villanueva | Elih | RHP | Luray | 2007 | 27 | 2008 | 2011 |
| Voigt | Jack | OF | Staunton | 9 | 1987 | 1992-1998 | |
| Vukovich | George | OF | Harrisonburg | 4 | 1977 | 1980-1985 | |
| Walling | Denny | 3B | Waynesboro | 1975 | 1(1) | 1975 | 1975-1992 |
| Watkins | Pat | OF | Staunton | 1992 | 1(32) | 1993 | 1997-1999 |
| White | Tyler | 3B | Haymarket | 2010 | 33 | 2013 | 2016- |
| Whitmore | Darrell | OF | Front Royal | 2 | 1990 | 1993-1995 | |
| Williams | Mike | RHP | Harrisonburg | 1989 | 14 | 1990 | 1992-2003 |
| Williamson | Mac | OF | Harrisonburg | 2011 | 3 | 2012 | 2015-2018 |
| Wilson | Cody | OF | Winchester | 2017 | 13 | 2018 | 2021- |
| Wilson | Jacob | 2B | Luray | 2009 | 10 | 2012 | 2021- |
| Wimmers | Alex | RHP | Luray | 2008 | 1(21) | 2010 | 2016-2017 |
| Yarbrough | Ryan | LHP | Luray | 2012 | 4 | 2014 | 2018- |
| Ziegler | Brad | RHP | New Market | 2000 | 20 | 2003 | 2008-2018 |
| Zoccolillo | Peter | OF | Front Royal | 1998 | 23 | 1999 | 2003 |
| Zuber | Jon | 1B | Harrisonburg | 1991 | 12 | 1992 | 1996-1998 |